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The accumulation of autophagosomes early after TBI reflects a deleterious effect in which impaired lysosomal function and autophagosome clearance lead to the accumulation of ubiquitinated proteins and protein aggregates, resulting in neuronal cell death

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(2006) Lower rate of preeclampsia after antioxidant supplementation in pregnant women with low antioxidant status

The advantage of non-cleavable linkers is their extremely high stability in plasma, with virtually no non-specific release, resulting in lower off-target toxicity